HTR1F antibody (Cytoplasmic Domain)

Catalog No. ABIN302579

Product Details anti-HTR1F Antibody

Target: HTR1F (5-Hydroxytryptamine (serotonin) Receptor 1F (HTR1F))

Binding Specificity: Cytoplasmic Domain

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTR1F antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects 5-HT1F Receptor (HTR1F) at 3rd cytoplasmic domain.

Cross-Reactivity (Details): Species reactivity (expected):Monkey, Bovine, Horse, Rabbit, Guinea pig.
Species reactivity (tested):Human.

Purification: Immunoaffinity chromatography

Immunogen: HTR1F antibody was raised against synthetic peptide from 3rd cytoplasmic domain of human HTR1F / 5-HT1F.

Application Details

Application Notes: Immunohistochemistry (6.5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for HTR1F

Target: HTR1F (5-Hydroxytryptamine (serotonin) Receptor 1F (HTR1F))

Alternative Name: Serotonin Receptor 1F (HTR1F) (HTR1F Products)

Synonyms: 5-HT-1F antibody, 5-HT1F antibody, 5HT6 antibody, HTR1EL antibody, MR77 antibody, Htr1eb antibody, 5htr1e antibody, 5htr1f antibody, 5-hydroxytryptamine receptor 1F antibody, 5-hydroxytryptamine (serotonin) receptor 1F antibody, uncharacterized LOC100406194 antibody, HTR1F antibody, Htr1f antibody, LOC100406194 antibody

Background: 5-HT1F, a Serotonin Receptor, is negatively coupled to adenylate cyclase. Selective 5-HT1F agonists may prove therapeutic in the treatment of migraine headache, lacking the side effects associated with the agonists of the 5-HT1B and 5-HT1D receptors.Synonyms: 5-HT-1F, 5-hydroxytryptamine receptor 1F, HTR1EL

Gene ID: 3355

NCBI Accession: NP_000857

UniProt: P30939

Pathways: JAK-STAT Signaling