PLGF antibody

Catalog No. ABIN3026241

Product Details anti-PLGF Antibody

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLGF antibody is un-conjugated

Application: ELISA, Functional Studies (Func)

Purification: Protein G purified PLGF antibody

Immunogen: Recombinant human protein was used as the immunogen for this PLGF antibody.

Clone: PLGF94

Isotype: IgG1 kappa

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the PLGF antibody to be titered up or down for optimal performance.\. ELISA: order BSA/azide-free format,Functional testing: order BSA/azide free format

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the PLGF antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for PLGF

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Alternative Name: PLGF (PGF Products)

Synonyms: D12S1900 antibody, PGFL antibody, PLGF antibody, PlGF-2 antibody, SHGC-10760 antibody, AI854365 antibody, PIGF antibody, Plgf antibody, PlGF antibody, placental growth factor antibody, placenta growth factor antibody, PGF antibody, Pgf antibody, PLGF antibody

Background: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast-, platelet derived-, vascular endothelial- and placenta- growth factor (PLGF). Like vascular endothelial growth factor, several PLGF variants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.

Gene ID: 5228

Pathways: VEGFR1 Specific Signals