ADRA2A antibody (C-Term)

Catalog No. ABIN3029880

Product Details anti-ADRA2A Antibody

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human alpha 2a Adrenergic Receptor (FGYCNSSLNPVIYTIFNH) was used as the immunogen for this alpha 2a Adrenergic Receptor antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the alpha 2a Adrenergic Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the alpha 2a Adrenergic Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for ADRA2A

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Alternative Name: alpha 2a Adrenergic Receptor (ADRA2A Products)

Synonyms: ADRA2A antibody, AW122659 antibody, Adra-2 antibody, Adra-2a antibody, alpha(2A)AR antibody, alpha2-C10 antibody, alpha2A antibody, alpha2A-AR antibody, ADRA2 antibody, ADRA2R antibody, ADRAR antibody, ALPHA2AAR antibody, ZNF32 antibody, CA2-47 antibody, RATRG20 antibody, RG20 antibody, PORA2AR antibody, adrenoceptor alpha 2A antibody, alpha-2A adrenergic receptor-like antibody, adrenergic receptor, alpha 2a antibody, adra2a antibody, ADRA2A antibody, LOC100414445 antibody, Adra2a antibody

Background: Alpha-2-adrenergic receptor(ADRA2), also known as platelet type adrenoceptor alpha-2A ,is a member of G protein-coupled receptor superfamily. This gene, which can identify a DraI RFLP of the ADRAR gene, mapped to 10q23-q25, is found in the distal region of mouse chromosome 19 and abundantly expressed in giant cell. ADRA2 acts a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. It has 3 highly homologous subtypes: ADRA2A, ADRA2B and ADRA2C. Studies in mouse suggested that both the ADRA2A and ADRA2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. ADRA2A receptors inhibited transmitter release at high stimulation frequencies, whereas the ADRA2C subtype modulated neurotransmission at lower levels of nerve activity.

UniProt: P08913

Pathways: EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity