BMPR1B antibody (Middle Region)

Catalog No. ABIN3030189

Product Details anti-BMPR1B Antibody

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR1B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human Bone Morphogenetic Protein Receptor Type IB (FCYFRYKRQETRPRYS) was used as the immunogen for this BMPR1B antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the BMPR1B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the BMPR1B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for BMPR1B

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Alternative Name: BMPR1B (BMPR1B Products)

Synonyms: ALK6 antibody, BMPR-IB antibody, FecB antibody, alk-6 antibody, alk6 antibody, cdw293 antibody, alk6b antibody, zgc:172219 antibody, BMPR1B antibody, AI385617 antibody, ALK-6 antibody, AV355320 antibody, Acvrlk6 antibody, Alk6 antibody, BMPR-1B antibody, CFK-43a antibody, SKR6 antibody, BR1b antibody, alk6tr antibody, bmpr1b antibody, zALK-6 antibody, zgc:92220 antibody, CDw293 antibody, BMP15 antibody, BMPRIB antibody, RPK-1 antibody, bone morphogenetic protein receptor type 1B antibody, bone morphogenetic protein receptor, type IBb antibody, bone morphogenetic protein receptor, type 1B antibody, bone morphogenetic protein receptor, type IBa antibody, BMPR1B antibody, bmpr1b antibody, bmpr1bb antibody, Bmpr1b antibody, bmpr1ba antibody

Background: Bone Morphogenetic Protein Receptor Type IB, also known as ALK6, is a protein which in humans is encoded by the BMPR1B gene. It is a member of the bone morphogenetic protein(BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine(threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. By analysis of a monochromosome hybrid mapping panel and by FISH, Astrom et al.(1999) mapped the BMPR1B gene to chromosome 4q22-q24. Ide et al.(1997) compared BMP receptor expression in normal and cancerous prostate tissues. While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue.

UniProt: O00238