CTNNA1 antibody (AA 143-292)

Catalog No. ABIN3030328

Product Details anti-CTNNA1 Antibody

Target: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Binding Specificity: AA 143-292

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTNNA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 143-292) was used as the immunogen for this alpha Catenin antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the alpha Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the alpha Catenin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CTNNA1

Target: CTNNA1 (Catenin (Cadherin-Associated Protein), alpha 1, 102kDa (CTNNA1))

Alternative Name: alpha Catenin (CTNNA1 Products)

Synonyms: CAP102 antibody, 2010010M04Rik antibody, AA517462 antibody, AI988031 antibody, Catna1 antibody, CG17947 antibody, CT39986 antibody, Dalpha-Cat antibody, Dalpha-cat antibody, DalphaC antibody, Dalphacat antibody, Dmcatp antibody, Dmel\\CG17947 antibody, a-Cat antibody, a-cat antibody, alpha-CAT antibody, alpha-cat antibody, alpha-catenin antibody, alpha-ctn antibody, alphaCAT antibody, alphaCat antibody, alphacat antibody, Alpha-Cat antibody, dgri_GLEANR_3829 antibody, DgriGH19548 antibody, GH19548 antibody, ctnna antibody, cap102 antibody, catna1 antibody, ctnna1 antibody, catenin alpha 1 antibody, catenin (cadherin associated protein), alpha 1 antibody, alpha Catenin antibody, catenin alpha-1 antibody, catenin (cadherin-associated protein), alpha 1 antibody, catenin alpha 1 S homeolog antibody, CTNNA1 antibody, Ctnna1 antibody, alpha-Cat antibody, Dgri\alpha-Cat antibody, Tsp_10127 antibody, ctnna1 antibody, ctnna1.S antibody

Background: Alpha Catenin is a protein that in humans is encoded by the CTNNA1 gene. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.

Gene ID: 1495

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location