Factor VIII antibody (Middle Region)

Catalog No. ABIN3030544

Product Details anti-Factor VIII Antibody

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor VIII antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human F8 (APVLQDFRSLNDSTN) was used as the immunogen for this Factor VIII antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Factor VIII antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Factor VIII antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Alternative Name: Factor VIII (F8 Products)

Synonyms: fb61d02 antibody, wu:fb61d02 antibody, Cf-8 antibody, Cf8 antibody, FVIII antibody, AHF antibody, DXS1253E antibody, F8B antibody, F8C antibody, HEMA antibody, coagulation factor VIIi antibody, coagulation factor VIII antibody, coagulation factor VIII, procoagulant component antibody, f7i antibody, F8 antibody

Background: Coagulation Factor VIII (FVIII) is an essential blood-clotting protein. By in situ hybridization, Tantravahi et al.(1986) concluded that the F8 gene is located in the proximal part of chromosome Xq28 with probes DX13 and St14 distally located. The F8 gene encodes coagulation Factor VIII, a large plasma glycoprotein that functions in the blood coagulation cascade as a cofactor for the F9a-dependent activation of F10. Factor VIII is activated proteolytically by a variety of coagulation enzymes, including thrombin(F2). It is tightly associated in the blood with VWF, which serves as a protective carrier protein for Factor VIII (Toole et al., 1984, Hoyer, 1994).

UniProt: P00451