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GCN2 antibody (Middle Region)

EIF2AK4 Reactivity: Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030880
  • Target See all GCN2 (EIF2AK4) Antibodies
    GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))
    Binding Specificity
    • 19
    • 15
    • 10
    • 9
    • 8
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 57
    • 43
    • 22
    • 1
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 83
    • 3
    • 2
    Rabbit
    Clonality
    • 78
    • 10
    Polyclonal
    Conjugate
    • 33
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GCN2 antibody is un-conjugated
    Application
    • 74
    • 43
    • 38
    • 15
    • 14
    • 14
    • 10
    • 8
    • 8
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the middle region of mouse GCN2 (ATDHLAFTAEGKQDDQAGD) was used as the immunogen for this GCN2 antibody.
    Isotype
    IgG
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  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the GCN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the GCN2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    GCN2 (EIF2AK4) (Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))
    Alternative Name
    GCN2 (EIF2AK4 Products)
    Synonyms
    EIF2AK4 antibody, Gcn2-like antibody, GCN2 antibody, 2610011M03 antibody, MGCN2 antibody, eukaryotic translation initiation factor 2 alpha kinase 4 antibody, eukaryotic translation initiation factor 2-alpha kinase 4 antibody, eIF-2-alpha kinase GCN2 antibody, EIF2AK4 antibody, LOC579979 antibody, LOC100187226 antibody, eif2ak4 antibody, Eif2ak4 antibody
    Background
    Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4, also called GCN2 (General control nonderepressible 2), is an enzyme that in humans is encoded by the EIF2AK4 gene. It belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. Hartz(2005) mapped the gene to chromosome 15q15.1 based on an alignment of the protein sequence with the genomic sequence. Berlanga et al.(1999) demonstrated that GCN2 immunopurified from mouse liver extracts could phosphorylate rabbit Eif2 in vitro. Serum starvation increased the level of phosphorylated EIF2-alpha more than 2-fold in human embryonic kidney cells transfected with mouse Eif2ak4. Costa-Mattioli et al.(2005) reported a unique feature of hippocampal slices from GCN2-null mice: in CA1, a single 100-Hz train induced a strong and sustained long-term potentiation(late LTP or L-LTP), which was dependent on transcription and translation.
    UniProt
    Q9QZ05
    Pathways
    ER-Nucleus Signaling, Hepatitis C
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