OPTN antibody (AA 241-577)

Catalog No. ABIN3032098

Product Details anti-OPTN Antibody

Target: OPTN (Optineurin (OPTN))

Binding Specificity: AA 241-577

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OPTN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 241-577) was used as the immunogen for this Optineurin antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Optineurin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Optineurin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for OPTN

Target: OPTN (Optineurin (OPTN))

Alternative Name: Optineurin (OPTN Products)

Synonyms: nrp antibody, fip2 antibody, hip7 antibody, hypl antibody, glc1e antibody, tfiiia-intp antibody, ALS12 antibody, FIP2 antibody, GLC1E antibody, HIP7 antibody, HYPL antibody, NRP antibody, TFIIIA-INTP antibody, Fip2 antibody, 4930441O07Rik antibody, fj52f04 antibody, si:ch211-240l19.3 antibody, wu:fj52f04 antibody, zgc:66386 antibody, zgc:77868 antibody, optineurin antibody, optineurin L homeolog antibody, OPTN antibody, optn antibody, Optn antibody, optn.L antibody

Background: OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein Optineurin which may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize < a href=../search_result.php?search_txt=TNFa>tumor necrosis factor-alpha or < a href=../search_result.php?search_txt=fas ligand>Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. It may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the < a href=../search_result.php?search_txt=rab8>RAB8, < a href=../search_result.php?search_txt=huntingtin>Huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene ID: 10133

Pathways: M Phase