SHBG antibody (AA 30-210)

Catalog No. ABIN3032554

Product Details anti-SHBG Antibody

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Binding Specificity: AA 30-210

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHBG antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 30-210) was used as the immunogen for this SHBG antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the SHBG antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SHBG antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for SHBG

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Alternative Name: SHBG (SHBG Products)

Synonyms: ABP antibody, SBP antibody, TEBG antibody, Abpa antibody, shbgl antibody, wu:fb66h07 antibody, wu:fd55b08 antibody, zgc:123063 antibody, shbg antibody, sex hormone binding globulin antibody, sex hormone-binding globulin antibody, sex hormone binding globulin L homeolog antibody, SHBG antibody, Shbg antibody, shbg antibody, shbg.L antibody

Background: Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce it include the brain, uterus, testes, and placenta. It has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.

Gene ID: 6462

Pathways: Hormone Transport