SCN5A antibody (Internal Region)
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- Target See all SCN5A Antibodies
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Goat
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Clonality
- Polyclonal
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Conjugate
- This SCN5A antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificity
- This antibody recognises SCN5A.
- Purification
- Immunoaffinity Chromatography.
- Immunogen
- Amino Acids (C)ETDDQSPEKIN from an internal region of human SCN5A.
- Top Product
- Discover our top product SCN5A Primary Antibody
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- Application Notes
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Immunohistochemistry on Paraffin Sections (5-10 μg/mL). ELISA (1/32000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris buffered saline containing 0.5 % BSA and 0.02 % sodium azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid cycles of freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody (in aliquots) at-20 °C. Dilute only prior to immediate use.
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- Target
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
- Alternative Name
- SCN5A (SCN5A Products)
- Synonyms
- Nav1.5 antibody, Nav1.5c antibody, SkM1 antibody, SkM2 antibody, mH1 antibody, CDCD2 antibody, CMD1E antibody, CMPD2 antibody, HB1 antibody, HB2 antibody, HBBD antibody, HH1 antibody, ICCD antibody, IVF antibody, LQT3 antibody, PFHB1 antibody, SSS1 antibody, VF1 antibody, SCAL antibody, sodium voltage-gated channel alpha subunit 5 antibody, sodium channel, voltage-gated, type V, alpha antibody, SCN5A antibody, Scn5a antibody
- Background
- Scn5a encodes the alpha subunit of the type V voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type V channel has been shown to be tetrodotoxin-resistant. Scn5a null mice experience intrauterine lethality. Mutations in the SCN5A gene are responsible for several heart conditions, including the chromosome 3-linked form of long LQT and Brugada syndrome.Synonyms: CDCD2, HB1, HB2, HBBD, HH1, LQT3, Nav1.5, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type 5 subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5
- Gene ID
- 6331
- NCBI Accession
- NP_000326
- UniProt
- Q14524
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