IRAK3 antibody (C-Term)

Catalog No. ABIN3042834

Product Details anti-IRAK3 Antibody

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Binding Specificity: AA 543-562, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK3 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Interleukin-1 receptor-associated kinase 3(IRAK3) detection. Tested with WB in Human.

Sequence: WFPKYIVPSQ DLRPYKVNID

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Interleukin-1 receptor-associated kinase 3(IRAK3) detection. Tested with WB in Human.
Gene Name: interleukin-1 receptor-associated kinase 3
Protein Name: Interleukin-1 receptor-associated kinase 3

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IRAKM(543-562aa WFPKYIVPSQDLRPYKVNID).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IRAK3

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Alternative Name: IRAK3 (IRAK3 Products)

Synonyms: IRAK3 antibody, si:dkey-150i15.2 antibody, ASRT5 antibody, IRAKM antibody, IrakM antibody, 4833428C18Rik antibody, AI563835 antibody, IRAK-M antibody, interleukin 1 receptor associated kinase 3 antibody, interleukin-1 receptor-associated kinase 3 antibody, IRAK3 antibody, irak3 antibody, Irak3 antibody

Background: Interleukin-1 receptor-associated kinase 3, also called IRAK3 or IRAKM is an enzyme that in humans is encoded by the IRAK3 gene. The IRAKM gene consists of 12 exons spanning a region of approximately 60 kb in chromosome 12q14.3. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma.

Synonyms: ASRT5 antibody|IL 1 receptor associated kinase M antibody|IL-1 receptor-associated kinase M antibody|IL1 receptor associated kinase M antibody|Interleukin 1 receptor associated kinase 3 antibody|Interleukin 1 receptor associated kinase M antibody|Interleukin-1 receptor-associated kinase 3 antibody|IRAK 3 antibody|IRAK M antibody|IRAK-3 antibody|IRAK-M antibody|IRAK3 antibody|IRAK3_HUMAN antibody

UniProt: Q9Y616

Pathways: TLR Signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades