TEK antibody (AA 641-830)

Catalog No. ABIN3043418

Product Details anti-TEK Antibody

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Binding Specificity: AA 641-830

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEK antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Angiopoietin-1 receptor(TEK) detection. Tested with WB in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Angiopoietin-1 receptor(TEK) detection. Tested with WB in Human.
Gene Name: TEK tyrosine kinase, endothelial
Protein Name: Angiopoietin-1 receptor

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TIE2 recombinant protein (Position: Q641-I830). Human TIE2 shares 91% amino acid (aa) sequence identity with mouse TIE2.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for TIE2 is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Alternative Name: TEK (TEK Products)

Background: TIE2, also known as TEK tyrosine kinase, TIE2 gene is mapped to 9p21.2. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

Synonyms: Angiopoietin 1 receptor antibody|Angiopoietin-1 receptor antibody|CD202b antibody|CD202b antigen antibody|CD202b antigen antibody|Endothelial tyrosine kinase antibody|Endothelium specific receptor tyrosine kinase 2 antibody|hTIE 2 antibody|hTIE 2 antibody|hTIE2 antibody|hTIE2 antibody|Hyk antibody|p140 TEK antibody|p140 TEK antibody|Soluble TIE2 variant 1 antibody|Soluble TIE2 variant 2 antibody|TEK antibody|tek tyrosine kinase antibody|TEK tyrosine kinase endothelial antibody|tek tyrosine kinase, endothelial antibody|TIE 2 antibody|TIE2_HUMAN antibody|Tunica interna endothelial cell kinase antibody|Tyrosine kinase with Ig and EGF homology domains 2 antibody|Tyrosine protein kinase receptor TEK antibody|Tyrosine protein kinase receptor TIE 2 antibody|Tyrosine protein kinase receptor TIE 2 antibody|Tyrosine-protein kinase receptor TEK antibody|Tyrosine-protein kinase receptor TIE-2 antibody|Venous malformations multiple cutaneous and mucosal antibody|VMCM 1 antibody|VMCM antibody|VMCM1 antibody

Gene ID: 7010

UniProt: Q02763

Pathways: RTK Signaling, Growth Factor Binding