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PKC gamma antibody (C-Term)

PRKCG Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043714
  • Target See all PKC gamma (PRKCG) Antibodies
    PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
    Binding Specificity
    • 20
    • 15
    • 15
    • 13
    • 11
    • 9
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 665-685, C-Term
    Reactivity
    • 107
    • 96
    • 67
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Rat
    Host
    • 142
    • 5
    • 1
    Rabbit
    Clonality
    • 127
    • 21
    Polyclonal
    Conjugate
    • 52
    • 15
    • 13
    • 9
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PKC gamma antibody is un-conjugated
    Application
    • 128
    • 59
    • 40
    • 39
    • 32
    • 18
    • 12
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Protein kinase C gamma type(PRKCG) detection. Tested with WB in Human,Mouse,Rat.
    Sequence
    IDQADFQGFT YVNPDFVHPD A
    Cross-Reactivity (Details)
    Predicted Cross Reactivity: human, mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Characteristics
    Rabbit IgG polyclonal antibody for Protein kinase C gamma type(PRKCG) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: protein kinase C, gamma
    Protein Name: Protein kinase C gamma type(PKC-gamma)
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human PKC gamma(665-685aa IDQADFQGFTYVNPDFVHPDA), identical to the related rat and mouse sequences.
    Isotype
    IgG
    Top Product
    Discover our top product PRKCG Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Gan, Wang, Zhao, Wu, Yang, Peng: "5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors." in: Drug design, development and therapy, Vol. 10, pp. 711-21, (2016) (PubMed).

    Zhang, Xu, Song, Yao, Ji: "Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity." in: Journal of translational medicine, Vol. 12, pp. 236, (2015) (PubMed).

  • Target
    PKC gamma (PRKCG) (Protein Kinase C, gamma (PRKCG))
    Alternative Name
    PRKCG (PRKCG Products)
    Synonyms
    PRKCG antibody, PKC-gamma antibody, PKCC antibody, PKCG antibody, SCA14 antibody, PKCgamma antibody, Pkcc antibody, Prkcc antibody, PKC antibody, PKCI antibody, Prkc antibody, RATPKCI antibody, protein kinase C gamma antibody, protein kinase C, gamma antibody, protein kinase C gamma type antibody, PRKCG antibody, Prkcg antibody, LOC484316 antibody
    Background
    The gamma isotype of protein kinase C(PKC gamma) is a member of the classical PKC(cPKC) subfamily which is activated by Ca(2+) and diacylglycerol in the presence of phosphatidylserine. Physiologically, PKC gamma is activated by a mechanism coupled with receptor-mediated breakdown of inositol phospholipid as other cPKC isotypes such as PKC alpha and PKC beta. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons, while PKC alpha and PKC beta are expressed in many tissues in addition to the brain. Within the brain, PKC gamma is the most abundant in the cerebellum, hippocampus and cerebral cortex, where the existence of neuronal plasticity has been demonstrated. PKC gamma gene is mutated in spinocerebellar ataxia type 14(SCA14). Verbeek et al.(2005) point out the specific alterations in mutant PKC gamma function that could lead to the selective neuronal degeneration of SCA14.

    Synonyms: KPCG_HUMAN antibody|MGC57564 antibody|OTTHUMP00000067291 antibody|PKC-gamma antibody|PKCC antibody|PKCG antibody|PRKCG antibody|Protein kinase C gamma antibody|Protein kinase C gamma polypeptide antibody|Protein kinase C gamma type antibody|Protein kinase C, gamma antibody|SCA 14 antibody|SCA14 antibody
    UniProt
    P05129
    Pathways
    WNT Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGF Signaling
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