Bcl-2 antibody

Catalog No. ABIN306549

The Sheep Polyclonal anti-Bcl-2 antibody (ABIN306549) specifically detects Bcl-2 in WB, IF and IP. The antibody is reactive with Human, Rat and Dog samples.

Quick Overview for Bcl-2 antibody (ABIN306549)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity: Human, Rat, Dog

Host: Sheep

Clonality: Polyclonal

Conjugate: This Bcl-2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-Bcl-2 Antibody

Purpose: Sheep anti bcl-2

Characteristics: Human hematopoetic malignancies are often characterized by gene rearrangements that deregulate gene expression. Antibodies to human bcl-2 (B cell leukemia/lymphoma 2) are directed against the gene isolated at the chromosomal breakpoint t(14,18) Bcl-2 which suppress programmed cell death (apoptosis) and appears to be modulated by association with bax, a cell death promoter.

Purification: Ammonium Sulfate Precipitation

Isotype: IgG

Application Details

Application Notes: Western Blots at 1:5000, Immunoprecipitation - Empirical, Immunofluorescence 1:5000.

Restrictions: For Research Use only

Handling

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Alternative Name: bcl-2

Background: Hbcl2, sheep anti human bcl 2, bcl-2

UniProt: P10415

Pathways: MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling