p130 antibody

Catalog No. ABIN306630

The Mouse Monoclonal anti-p130 antibody (Clone KAB40) (ABIN306630) specifically detects p130 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for p130 antibody (ABIN306630)

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This p130 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: KAB40

Product Details anti-p130 Antibody

Purpose: Mouse anti Human p130

Characteristics: P130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107(collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors. This antibody recognizes both the phosphorylated and unphosphorylated forms of p130 at a MW of 130 kDa.

Purification: Protein A/G Chromatography

Isotype: IgG1

Application Details

Application Notes: Western Blots at 1:1000

Restrictions: For Research Use only

Handling

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for p130

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Alternative Name: p130

Background: P130, Retinoblastoma-like protein 2, RBR-2, PRB2

Molecular Weight: 130kDa

UniProt: Q08999, Q64700, O55081

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases