Retinoblastoma Protein (Rb) antibody

Catalog No. ABIN306637

This Mouse Monoclonal antibody specifically detects Retinoblastoma Protein (Rb) in . It exhibits reactivity toward Human, Mouse, Rat, Chicken and Mink.

Quick Overview for Retinoblastoma Protein (Rb) antibody (ABIN306637)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Reactivity: Human, Mouse, Rat, Chicken, Mink

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoblastoma Protein (Rb) antibody is un-conjugated

Application: Please inquire

Clone: XZ91

Product Details anti-Retinoblastoma Protein (Rb) Antibody

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Target Details for Retinoblastoma Protein (Rb)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Alternative Name: Rb (Retinoblastoma)

Background: The immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes. Synonyms: Retinoblastoma-associated protein, pRb, pp110, p105-Rb.

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases