PTGER3 antibody

Catalog No. ABIN306865

Product Details anti-PTGER3 Antibody

Target: PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3) (PTGER3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTGER3 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Cow, Human, Rat

Characteristics: Prostaglandin E2 Receptor Subtype EP3,Prostaglandins (PG's) are produced by the metabolism of arachidonic acid. PGE-2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues are mediated through binding to the PGE-2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP3 receptors are 365-425 amino acid proteins. There are currently 4 known isoforms of EP3 receptors named EP3A, 3B, 3C and 3D. Each of has different physiological function, but differ only in the carboxyl terminus and how they couple to their respective G-proteins. EP3 receptors are involved in water absorption, gastric acid secretion, uterine contraction, neurotransmitter release and the hydrolysis of fat cells (lipolysis). EP3 receptors also act as a mediator of neural inflammation. These receptors are mainly localized in the brain, kidney, stomach, uterus and ovaries.

Purification: Protein A/G Chromatography

Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human EP3 receptor protein and mouse myeloma cells.

Clone: 5F5

Isotype: IgG2a

Application Details

Application Notes: This antibody can be used for Western blot analysis (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for PTGER3

Target: PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3) (PTGER3))

Alternative Name: Prostaglandin-E2 receptor EP3 (PTGER3 Products)

Synonyms: PTGER3 antibody, EP3 antibody, EP3-I antibody, EP3-II antibody, EP3-III antibody, EP3-IV antibody, EP3e antibody, PGE2-R antibody, PTGEREP3 antibody, Rep3 antibody, rEP3a antibody, rEP3b antibody, Pgerep3 antibody, Ptgerep3 antibody, prostaglandin E receptor 3 antibody, prostaglandin E receptor 3 L homeolog antibody, prostaglandin E receptor 3 (subtype EP3) antibody, PTGER3 antibody, ptger3.L antibody, Ptger3 antibody

UniProt: P34980