PUMA antibody

Catalog No. ABIN308637

The Rabbit Polyclonal anti-PUMA antibody (ABIN308637) specifically detects PUMA in WB. The antibody is reactive with Mouse samples.

Quick Overview for PUMA antibody (ABIN308637)

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PUMA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PUMA Antibody

Cross-Reactivity: Human

Purification: affinity purified

Immunogen: Reacts with a 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-alpha and PUMA-beta forms of the protein. Recognizes both forms of the protein.

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for PUMA

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Alternative Name: PUMA

Background: A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. In human and mouse, PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53.

Pathways: p53 Signaling, Positive Regulation of Endopeptidase Activity