NPY2R antibody

Catalog No. ABIN317758

Product Details anti-NPY2R Antibody

Target: NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPY2R antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: NPY2-R antibody detects endogenous levels of NPY2-R protein.(region surrounding Asp42)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 1000approx. 1: 5000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.09 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NPY2R

Target: NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))

Alternative Name: Npy2r (NPY2R Products)

Synonyms: NPY2-R antibody, npy2r antibody, si:dkey-30k22.9 antibody, NPY-Y2 antibody, neuropeptide Y receptor Y2 antibody, NPY2R antibody, npy2r antibody, Npy2r antibody

Background: A gene on chromosome 4q31 encodes a 381 amino acid protein, NPY2-R(also designated Neuropeptide Y receptor Y2). NPY2-R is a member of the Gprotein-coupled receptor super-family, and like other members has seven putative transmembrane domains. However, NPY2-R gene consists of two exons, unlike the contiguous structure of other G-protein-coupled receptor genes. NPY2-R shares a 31 % sequence identity with NPY1-R. NPY2-R is expressed in the presynaptic membranes of the central nervous system, and to a lesser extent the peripheral nervous system. NPY2-R associates (from highest to lowest affinity) with carboxyl terminals of unphosphorylate Peptide YY (PYY) (phosphorylation of PYY greatly reduces its binding affinity), NPY, and Pancreatic Peptide. Depending on the cell type, NPY2-R couples with different G proteins, which act as different second messengers. NPY2-R reduces the effects of depolarization, calcium ion currents in arterial smooth muscle by through association with NPY. NPY2-R inhibits cholecystokinin octapeptide-induced, esophageal muscle contraction, through interactions with PYY and NPY.Synonyms: NPY-Y2 receptor, NPY2-R, Neuropeptide Y receptor 2, Y2 receptor

Molecular Weight: approx. 48 kDa

Gene ID: 18167

UniProt: P97295

Pathways: cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour