Mu Opioid Receptor 1 antibody

Catalog No. ABIN317766

Product Details anti-Mu Opioid Receptor 1 Antibody

Target: Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mu Opioid Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of MOR-1 protein.(region surrounding Ser57)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Mu Opioid Receptor 1

Target: Mu Opioid Receptor 1 (OPRM1) (Opioid Receptor, mu 1 (OPRM1))

Alternative Name: OPRM1 (OPRM1 Products)

Synonyms: LMOR antibody, M-OR-1 antibody, MOP antibody, MOR antibody, MOR1 antibody, OPRM antibody, MOP-R antibody, MOR-1 antibody, MOR-1O antibody, Oprm antibody, mor antibody, muOR antibody, MORA antibody, Oprrm1 antibody, or2 antibody, ZFOR2 antibody, OPRM1 antibody, opioid receptor mu 1 antibody, opioid receptor, mu 1 antibody, outer membrane protein OprM antibody, OPRM1 antibody, Oprm1 antibody, oprm1 antibody, oprM1 antibody

Background: Three types of opioid receptors have been cloned: mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. Most actions of exogenous opioids, such as morphine, are mediated through the μ-opioid receptor, including analgesia, tolerance and reward. In general, opioids modulate numerous central and peripheral processes including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.Synonyms: MOR1, Mu-type opioid receptor

Molecular Weight: approx. 48 kDa

Gene ID: 4988

NCBI Accession: NP_000905

UniProt: P35372

Pathways: cAMP Metabolic Process, Synaptic Membrane