TRHR antibody

Catalog No. ABIN317876

Product Details anti-TRHR Antibody

Target: TRHR (Thyrotropin-Releasing Hormone Receptor (TRHR))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRHR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TRHR

Target: TRHR (Thyrotropin-Releasing Hormone Receptor (TRHR))

Alternative Name: TRHR (TRHR Products)

Synonyms: TRH-R1 antibody, TRH-R antibody, GPCR antibody, trhr-A antibody, xtrhr antibody, TRH-RECEPTOR antibody, thyrotropin-releasing hormone receptor antibody, thyrotropin releasing hormone receptor antibody, thyrotropin releasing hormone receptor S homeolog antibody, Tsp_09695 antibody, Trhr antibody, TRHR antibody, trhr.S antibody

Background: Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide that stimulates, via its receptor in the anterior pituitary gland, the release of thyrotrophin (TSH) and prolactin. The TRH receptors, TRH-R1 and TRH-R2, are G protein-coupled proteins containing seven transmembrane domains and other conserved regions. In rat, two isoforms exist, TRH-R (412) and TRH-R (387), that differ at their carboxy termini. TRH receptors are distributed throughout the central and peripheral nervous systems and are present in a variety of tissues. TRH-R2 displays 50 % homology to TRH-R1 and is more restricted to the central nervous system than TRH-R1. Mutation in the TRH receptor gene is associated with isolated central hypothyroidism, a rare disorder characterized by insufficient TSH secretion resulting in low levels of thyroid hormones.Synonyms: TRH-R, Thyroliberin receptor 1, Thyrotropin-releasing hormone receptor

Molecular Weight: approx. 50 kDa