SPTBN1 antibody

Catalog No. ABIN317939

Product Details anti-SPTBN1 Antibody

Target: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTBN1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Spectrin β II antibody detects endogenous levels of Spectrin β II protein.(region surrounding Met687)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SPTBN1

Target: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Abstract: SPTBN1 Products

Synonyms: 9930031C03Rik antibody, AL033301 antibody, SPTB2 antibody, Spnb-2 antibody, Spnb2 antibody, elf1 antibody, elf3 antibody, mKIAA4049 antibody, ELF antibody, betaSpII antibody, Spnb1 antibody, spectrin beta, non-erythrocytic 1 antibody, spectrin, beta, non-erythrocytic 1 antibody, Sptbn1 antibody, SPTBN1 antibody

Background: Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin β I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of β-spectrin.Synonyms: Beta-II spectrin, Fodrin beta chain, SPTB2, Spectrin beta chain brain 1, Spectrin non-erythroid beta chain 1

Molecular Weight: approx. 275 kDa

Gene ID: 6711

NCBI Accession: NP_003119

UniProt: Q01082

Pathways: Regulation of Actin Filament Polymerization, Protein targeting to Nucleus