TRPC4 antibody (4th Cytoplasmic Loop)

Catalog No. ABIN351140

Product Details anti-TRPC4 Antibody

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Binding Specificity: 4th Cytoplasmic Loop

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for TRPC4.

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of rat TRPC4 conjugated to an immunogenic carrier protein was used as the antigen.

Isotype: IgG

Application Details

Application Notes: A concentration of 10-50 µg/ml is recommended.
The optimal dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TRPC4

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Alternative Name: TRPC4 (TRPC4 Products)

Synonyms: TRPC5 antibody, TRPC4 antibody, HTRP-4 antibody, HTRP4 antibody, TRP4 antibody, CCE1 antibody, STRPC4 antibody, Trp4 antibody, Trrp4 antibody, transient receptor potential cation channel subfamily C member 4 antibody, short transient receptor potential channel 4 antibody, transient receptor potential cation channel, subfamily C, member 4 antibody, TRPC4 antibody, LOC100538928 antibody, trpc4 antibody, Trpc4 antibody

Background: Function: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with NHERF. PROBABLE
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Short transient receptor potential channel 4, Trp4, Capacitative calcium entry channel 1, CCE1. GENE NAME: Trpc4.