BMPR1B antibody (C-Term)

Catalog No. ABIN357379

Product Details anti-BMPR1B Antibody

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to BMPR1B.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human BMPR1B.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-BMPR1B antibody (ABIN357379)

Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, (2009) (PubMed).

Target Details for BMPR1B

Target: BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))

Alternative Name: CDw293 / BMPR1B (BMPR1B Products)

Synonyms: ALK6 antibody, BMPR-IB antibody, FecB antibody, alk-6 antibody, alk6 antibody, cdw293 antibody, alk6b antibody, zgc:172219 antibody, BMPR1B antibody, AI385617 antibody, ALK-6 antibody, AV355320 antibody, Acvrlk6 antibody, Alk6 antibody, BMPR-1B antibody, CFK-43a antibody, SKR6 antibody, BR1b antibody, alk6tr antibody, bmpr1b antibody, zALK-6 antibody, zgc:92220 antibody, CDw293 antibody, BMP15 antibody, BMPRIB antibody, RPK-1 antibody, bone morphogenetic protein receptor type 1B antibody, bone morphogenetic protein receptor, type IBb antibody, bone morphogenetic protein receptor, type 1B antibody, bone morphogenetic protein receptor, type IBa antibody, BMPR1B antibody, bmpr1b antibody, bmpr1bb antibody, Bmpr1b antibody, bmpr1ba antibody

Background: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.Synonyms: ALK6, Bone morphogenetic protein receptor type-1B

Gene ID: 658, 9606

UniProt: O00238