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TEK antibody (pTyr1113)

TEK Reactivity: Human EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN358489
  • Target See all TEK Antibodies
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    Binding Specificity
    • 19
    • 19
    • 16
    • 11
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1113
    Reactivity
    • 135
    • 66
    • 49
    • 22
    • 4
    • 3
    Human
    Host
    • 127
    • 17
    • 3
    • 2
    • 2
    Rabbit
    Clonality
    • 133
    • 18
    Polyclonal
    Conjugate
    • 69
    • 10
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This TEK antibody is un-conjugated
    Application
    • 80
    • 59
    • 40
    • 40
    • 36
    • 27
    • 14
    • 13
    • 12
    • 8
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects TEK pTyr1113. Predicted to cross react with Mouse and Zebrafish (100 % Antigen Homology).
    Purification
    Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1113 of human TEK.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TEK Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Dot Blot: 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    TEK (TEK Tyrosine Kinase, Endothelial (TEK))
    Alternative Name
    CD202b / TEK (TEK Products)
    Synonyms
    TEK antibody, DKFZp469E064 antibody, AA517024 antibody, Cd202b antibody, Hyk antibody, Tie2 antibody, tie-2 antibody, CD202B antibody, TIE-2 antibody, TIE2 antibody, VMCM antibody, VMCM1 antibody, Tie-2 antibody, tie2 antibody, TEK receptor tyrosine kinase antibody, angiopoietin-1 receptor antibody, TEK tyrosine kinase, endothelial antibody, TEK antibody, LOC100408334 antibody, tek antibody, Tek antibody
    Background
    The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations, the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK
    Molecular Weight
    125810 Da
    Gene ID
    83659, 9606
    UniProt
    Q02763
    Pathways
    RTK Signaling, Growth Factor Binding
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