AICDA antibody (N-Term)

Catalog No. ABIN374978

The Goat Polyclonal anti-AICDA antibody is suitable to detect AICDA in samples from Human, Cow and Pig. It has been validated for WB and EIA.

Quick Overview for AICDA antibody (N-Term) (ABIN374978)

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Reactivity: Human, Cow, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This AICDA antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-AICDA Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to AID.

Cross-Reactivity (Details): Species reactivity (expected):Pig, Cow.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence RRKFLYQFKNVR-C, from the N Terminus of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/1000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AICDA

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Alternative Name: AICDA / AID

Background: AID or AICDA (activation-induced cytidine deaminase) is an RNA editing deaminase involved in somatic hypermutation, gene conversion, and class switch recombination. Expression of AID is restricted to stimulated B lymphocytes and it is required for several crucial steps of B cell terminal differentiation necessary for efficient antibody responses. It catalyses the deamination of Cytidine to uridine and ammonia and is strongly expressed in lymph nodes and tonsils. Defects in AICDA are the cause of autosomal recessive hyper IgM immunodeficiency syndrome type 2 (HIGM2) which is characterized by normal or elevated serum IgM levels with the absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections.Synonyms: Activation-induced cytidine deaminase, Cytidine aminohydrolase

Gene ID: 57379, 9606

UniProt: Q9GZX7

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response