TIMP4 antibody (HRP)

Catalog No. ABIN375479

Product Details anti-TIMP4 Antibody (HRP)

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIMP4 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Characteristics: The antibody detects: Human TIMP-4
To insure lot-to-lot consistency, each batch of product is tested by IHC to conform with the characteristics of a standard reference reagent.

Purification: Purified

Immunogen: Recombinant TIMP-4

Clone: SB30c

Isotype: IgG2a

Application Details

Application Notes: Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Sample Volume: 1 mL

Restrictions: For Research Use only

Handling

Format: Liquid

Handling Advice: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Target Details for TIMP4

Target: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Alternative Name: TIMP-4 (TIMP4 Products)

Synonyms: TIMP4 antibody, TIMP-4 antibody, timp4 antibody, TIMP metallopeptidase inhibitor 4 antibody, TIMP metallopeptidase inhibitor 4, tandem duplicate 3 antibody, tissue inhibitor of metalloproteinase 4 antibody, TIMP4 antibody, timp4.3 antibody, Timp4 antibody

Background: Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs therefore play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4 (approx. 23 kDa), unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. It has been shown to be an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9 with a preference for MMP-2 and MMP-7.