Integrin beta 2 antibody

Catalog No. ABIN376376

The Rat Monoclonal anti-Integrin beta 2 antibody is suitable to detect Integrin beta 2 in samples from Mouse. It has been validated for FACS, WB, IP, ELISA, IHC (fro), ICC and IHC (p).

Quick Overview for Integrin beta 2 antibody (ABIN376376)

Target: Integrin beta 2 (ITGB2)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin beta 2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: C71-16

Product Details anti-Integrin beta 2 Antibody

Purpose: Rat Anti-Mouse CD18-LE/AF

Specificity: Mouse CD18, Mr 95 kDa

Characteristics: Low Endotoxin/Azide Free Anti-Mouse CD18 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, western blotting, and immunoprecipitation assays.

Endotoxin Level: Low Endotoxin

Immunogen: Cell membrane glycoproteins derived from mouse BW5147 T cell lymphoma cells

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: 2-8°C

Target Details for Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Alternative Name: CD18

Background: CD18 represents the common β 2 integrin subunit that associates non-covalently with the α β chains of CD11a/LFA-1a, CD11b/Mac-1, and CD11c to form various integrin heterodimers. It is expressed strongly on lymphocytes and monocytes, and weakly on granulocytes, CD18 mediates a variety of heterotypic and homotypic intercellular adhesion reactions, and it regulates the ligand-binding activities of the various CD11/CD18 complexes.

Gene ID: 16414

UniProt: P11835

Pathways: NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation