c-MET antibody (Catalytic Domain)

Catalog No. ABIN387745

This Mouse Monoclonal antibody specifically detects c-MET in WB and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for c-MET antibody (Catalytic Domain) (ABIN387745)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 4AT247

Product Details anti-c-MET Antibody

Binding Specificity: Catalytic Domain

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This monoclonal antibody is generated from mice immunized with purified recombinant protein encoding the catalytic domain of human Met.

Isotype: IgG1

Application Details

Application Notes: IF: 1:100. WB: 1:1000. WB: 1:100~500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: MET/HGFR

Background: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 155541

Gene ID: 4233

NCBI Accession: NP_000236, NP_001120972

UniProt: P08581

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor