CHEK1 antibody

Catalog No. ABIN387806

There are 2+ publications for this product available. The Mouse Monoclonal anti-CHEK1 antibody is suitable to detect CHEK1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for CHEK1 antibody (ABIN387806)

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This CHEK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 2G1D5

Product Details anti-CHEK1 Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This monoclonal antibody is generated from mice immunized with Ni-NTA purified recombinant protein CHK1 expressed in E. Coli strain M15.

Isotype: IgM

Application Details

Application Notes: WB: 1:1,000~4,000. WB: 1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CHEK1 antibody (ABIN387806)

Yuan, Cui, Wang, Ke, Wang, Lou, Gao, Qu: "Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways." in: Biochimica et biophysica acta, Vol. 1830, Issue 10, pp. 4907-16, (2013) (PubMed).

Greenow, Clarke, Jones: "Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation." in: Oncogene, Vol. 28, Issue 11, pp. 1443-53, (2009) (PubMed).

Target Details for CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Alternative Name: CHK1

Molecular Weight: 54434

Gene ID: 1111

NCBI Accession: NP_001107593, NP_001107594, NP_001231775, NP_001265

UniProt: O14757

Pathways: p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair