GDF2 antibody (N-Term)

Catalog No. ABIN388817

There are 2+ publications for this product available. The Rabbit Polyclonal anti-GDF2 antibody is suitable to detect GDF2 in samples from Human and Mouse. It has been validated for WB and IHC (p).

Quick Overview for GDF2 antibody (N-Term) (ABIN388817)

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB2206

Product Details anti-GDF2 Antibody

Binding Specificity: AA 8-37, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This BMP9 (GDF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human BMP9 (GDF2).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GDF2 antibody (ABIN388817)

Herrera, García-Álvaro, Cruz, Walsh, Fernández, Roncero, Fabregat, Sánchez, Inman: "BMP9 Is a Proliferative and Survival Factor for Human Hepatocellular Carcinoma Cells." in: PLoS ONE, Vol. 8, Issue 7, pp. e69535, (2013) (PubMed).

Herrera, van Dinther, Ten Dijke, Inman: "Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation." in: Cancer research, Vol. 69, Issue 24, pp. 9254-62, (2009) (PubMed).

Target Details for GDF2

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Alternative Name: BMP9 (GDF2)

Background: GDF2 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.

Molecular Weight: 47320

Gene ID: 2658

NCBI Accession: NP_057288

UniProt: Q9UK05

Pathways: Transition Metal Ion Homeostasis