GDF2 antibody (AA 371-420)

Catalog No. ABIN7227494

This Rabbit Polyclonal antibody specifically detects GDF2 in IHC, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for GDF2 antibody (AA 371-420) (ABIN7227494)

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-GDF2 Antibody

Binding Specificity: AA 371-420

Purpose: Rabbit Anti-BMP-9 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of BMP-9

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human BMP-9 protein at AA range: 371-420

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GDF2

Target: GDF2 (Growth Differentiation Factor 2 (GDF2))

Alternative Name: BMP-9

Background: Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9GDF2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in GDF2 are associated with hereditary hemorrhagic telangiectasia.

Gene ID: 2658

UniProt: Q9UK05

Pathways: Transition Metal Ion Homeostasis