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TDGF1 antibody (Internal Region)

TDGF1 Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401391
  • Target See all TDGF1 Antibodies
    TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))
    Binding Specificity
    • 15
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 60
    • 18
    • 8
    Human, Mouse
    Host
    • 42
    • 19
    • 2
    • 1
    Rabbit
    Clonality
    • 43
    • 20
    Polyclonal
    Conjugate
    • 22
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TDGF1 antibody is un-conjugated
    Application
    • 34
    • 32
    • 24
    • 13
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is specific for Cripto-1 protein. Expect cross-reactivity with Cripto-3 (TDGF2) based on very high levels of sequence conservation.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogen
    Synthetic peptide corresponding to an internal sequence of human Cripto-1 protein
    Isotype
    IgG
    Top Product
    Discover our top product TDGF1 Primary Antibody
  • Application Notes
    ELISA: 1/50,000 - 1/150,000. Western Blot: 1/500 - 1/2,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.80 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))
    Alternative Name
    TDGF1 / CRIPTO (TDGF1 Products)
    Synonyms
    CR antibody, CRGF antibody, CRIPTO antibody, CR1 antibody, cripto antibody, cb85 antibody, tdgf1 antibody, wu:fe01d04 antibody, zgc:109829 antibody, Cripto-1 antibody, cr1 antibody, cr1a antibody, frl-1 antibody, frl1 antibody, xcr1 antibody, TDGF1 antibody, tdgf3 antibody, cripto-3 antibody, teratocarcinoma-derived growth factor 1 antibody, teratocarcinoma-derived growth factor 1, member 3 L homeolog antibody, teratocarcinoma-derived growth factor 1, member 1 antibody, TDGF1 antibody, Tdgf1 antibody, tdgf1 antibody, tdgf1.3.L antibody, tdgf1.1 antibody
    Background
    Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor beta (TGFbeta) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.Synonyms: CRGF, Cripto-1 growth factor, Epidermal growth factor-like cripto protein CR1, Teratocarcinoma-derived growth factor 1
    Gene ID
    6997
    NCBI Accession
    NP_001167607
    UniProt
    P13385
    Pathways
    EGFR Signaling Pathway
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