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TDG antibody (N-Term)

This Rabbit Polyclonal antibody specifically detects TDG in WB and EIA. It exhibits reactivity toward Human and Mouse.
Catalog No. ABIN453412

Quick Overview for TDG antibody (N-Term) (ABIN453412)

Target

See all TDG Antibodies
TDG (Thymine-DNA Glycosylase (TDG))

Reactivity

  • 50
  • 18
  • 11
  • 2
  • 2
Human, Mouse

Host

  • 38
  • 12
Rabbit

Clonality

  • 41
  • 10
Polyclonal

Conjugate

  • 44
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This TDG antibody is un-conjugated

Application

  • 40
  • 14
  • 11
  • 11
  • 6
  • 6
  • 5
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Enzyme Immunoassay (EIA)
  • Binding Specificity

    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Specificity

    This antibody reacts to TDG.

    Purification

    Saturated Ammonium Sulfate (SAS) precipitation

    Immunogen

    KLH conjugated synthetic peptide selected from the N-terminal region of human TDG
  • Application Notes

    ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.25 mg/mL

    Buffer

    PBS with 0.09 % (W/V) sodium azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    4 °C/-20 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    TDG (Thymine-DNA Glycosylase (TDG))

    Alternative Name

    TDG

    Background

    The protein TDG belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.Synonyms: G/T mismatch-specific thymine DNA glycosylase

    Gene ID

    6996

    NCBI Accession

    NP_003202

    UniProt

    Q13569

    Pathways

    DNA Damage Repair, Chromatin Binding
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