NLRP12 antibody (C-Term)

Catalog No. ABIN453767

The Rabbit Polyclonal anti-NLRP12 antibody has been validated for WB and EIA. It is suitable to detect NLRP12 in samples from Human and Mouse.

Quick Overview for NLRP12 antibody (C-Term) (ABIN453767)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP12 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-NLRP12 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to NALP2.

Purification: Affinity chrmatography on Protein A

Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human NLRP12

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Alternative Name: NALP12

Background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.Synonyms: LRR and PYD domains-containing protein 12, Monarch-1, NACHT, NLRP12, PYPAF7, PYRIN-containing APAF1-like protein 7, RNO, Regulated by nitric oxide

Gene ID: 91662

NCBI Accession: NP_150639

UniProt: P59046

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome