SGPP2 antibody

Catalog No. ABIN4620340

This Rabbit Polyclonal antibody specifically detects SGPP2 in WB. It exhibits reactivity toward Human.

Quick Overview for SGPP2 antibody (ABIN4620340)

Target: SGPP2 (Sphingosine-1-Phosphate Phosphatase 2 (SGPP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGPP2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SGPP2 Antibody

Specificity: This antibody reacts to Sphingosine 1-Phosphate Phosphatase 2.

Purification: Affinity Purified

Immunogen: Synthetic peptide derived from the sphingosine 1-phosphate phosphatase 2 protein.

Application Details

Application Notes: Western Blot: 1: 400, Tissue lysate should be used at 10 - 50 g/lane.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Ship on dry ice. Store (in aliquots) at -20 °C only.

Target Details for SGPP2

Target: SGPP2 (Sphingosine-1-Phosphate Phosphatase 2 (SGPP2))

Alternative Name: SGPP2

Background: Sphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1 - 5)/Gprotein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family which play a role in attenuating intracellular S1P signaling.Synonyms: SPPase2, Sphingosine-1-phosphatase 2, Sphingosine-1-phosphate phosphatase 2

Gene ID: 130367

NCBI Accession: NP_689599

UniProt: Q8IWX5