DcR2 antibody (N-Term) (PE)

Catalog No. ABIN487317

Product Details anti-DcR2 Antibody (PE)

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Binding Specificity: AA 1-210, N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DcR2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: The antibody TRAIL-R4-01 reacts with TRAIL-R4, a 42 kDa transmembrane protein expressed on various blood cells.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: TNFRSF10D, DCR2, TRAIL-R4, TRUNDD, Decoy receptor 2, TRAIL receptor 4, Tumor necrosisfactor receptor superfamily member 10D, TNF-related apoptosis-inducing ligand receptor 4,TRAIL receptor with a truncated death domain

Purification: Size-Exclusion Chromatography.

Immunogen: TRAIL-R4 (aa 1-210) - hIgGhc fusion protein

Clone: TRAIL-R4-01

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry: 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS containing 15 mM Sdium Azide as preservative and 0.2 % (w/v) high-grade (Protease free) BSA as a stabilizing agent.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid prolonged exposure to light.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for DcR2

Target: DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))

Alternative Name: CD264 / TRAILR4 (TNFRSF10D Products)

Synonyms: TNFRSF10D antibody, CD264 antibody, DCR2 antibody, TRAIL-R4 antibody, TRAILR4 antibody, TRUNDD antibody, TNF receptor superfamily member 10d antibody, tumor necrosis factor receptor superfamily member 10D antibody, TNFRSF10D antibody, LOC716901 antibody

Background: TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4).Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D

Gene ID: 8793

UniProt: Q9UBN6

Pathways: Apoptosis