Integrin Alpha2b antibody

Catalog No. ABIN4880137

The Mouse Monoclonal anti-Integrin Alpha2b antibody is suitable to detect Integrin Alpha2b in samples from Human. It has been validated for FACS, IP, IF, ICC and IHC (fro).

Quick Overview for Integrin Alpha2b antibody (ABIN4880137)

Target: Integrin Alpha2b (CD41)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: M148

Product Details anti-Integrin Alpha2b Antibody

Purpose: CD41 Monoclonal Antibody [M148]

Specificity: This antibody recognises integrin alpha 2b, a 110-130 kDa transmembrane protein that is also known as CD41. CD41 associates with the integrin CD61 to form the CD41/CD61 (GPIIb/IIIa) heterodimer, a fibronectin receptor expressed in platelets. The antibody M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and certain other solid tumours. No binding is observed to marrow constituents other than platelets and megakaryocytes. The antibody M148 prevents aggregation of platelets.

Purification: Purified on protein A from tissue culture supernatant.

Immunogen: Homogenized human medulloblastoma tissue.

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration

Comment:

Myeloma/fusion partners:Cells from immunized Balb/c mice were fused with the P3X63Ag8.653 myeloma cell line

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41

Background: CD41, CD41B, GP2B, GPalpha IIb, GPIIb, GTA, HPA3, integrin alpha 2b, Integrin alpha-IIb, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), ITA2B, ITGA2B, ITGAB, platelet fibrinogen receptor, alpha subunit, Platelet membrane glycoprotein IIb, platelet-specific antigen BAK

Gene ID: 3689

OMIM: 607759

UniProt: P08514

Pathways: Integrin Complex