TNFRSF10A antibody (Extracellular Domain) (PE)

Catalog No. ABIN488159

Product Details anti-TNFRSF10A Antibody (PE)

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Binding Specificity: Extracellular Domain

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF10A antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a Human Death Receptor 4 (468 amino acids) expressed in most Human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: APO2, DR4, Death receptor 4, TRAIL receptor 1, TRAIL-R1, TNFRSF10A, Tumor necrosis factorreceptor superfamily member 10A, TNF-related apoptosis-inducing ligand receptor 1

Purification: Size-Exclusion Chromatography.

Immunogen: Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of theheavy chain of the Human IgG1.

Clone: DR-4-02

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry analysis: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS containing 15 mM sodium azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TNFRSF10A

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Alternative Name: CD261 / TRAILR1 (TNFRSF10A Products)

Synonyms: APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNFRSF10A antibody, TNF receptor superfamily member 10a antibody, tumor necrosis factor receptor superfamily member 26 antibody, tumor necrosis factor receptor superfamily, member 10a antibody, TNFRSF10A antibody, LOC510798 antibody

Background: TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).Synonyms: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A

Gene ID: 8797

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity