AACT antibody, ACT antibody, GIG25 antibody, A1AT antibody, PI antibody, alpha-1-PI antibody, A1A antibody, AAT antibody, PI1 antibody, PRO2275 antibody, alpha1AT antibody, Pi antibody, Spi1 antibody, MGC64429 antibody, serpina1d antibody, Aps antibody, SERPINA3-5 antibody, serpin family A member 3 antibody, alpha-1-antiproteinase F precursor antibody, serpin family A member 1 antibody, alpha-1-antitrypsin antibody, calumenin antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 antibody, SH2B adaptor protein 2 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog antibody, SERPINA3 antibody, LOC100008973 antibody, SERPINA1 antibody, LOC100328621 antibody, CALU antibody, Serpina1 antibody, serpina1.S antibody, serpina1 antibody, SPIA5 antibody, Sh2b2 antibody, Calu antibody, serpina1.L antibody
Background
α-1-antitrypsin,Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin., [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).,Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum., [Short peptide from AAT]: Secreted, extracellular space, extracellular matrix.,α-1 protease inhibitor, α-1-antiproteinase, Serpin A1 [Cleaved into: Short peptide from AAT