Collagen IV antibody
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- Target See all Collagen IV (COL4) Antibodies
- Collagen IV (COL4) (Collagen, Type IV (COL4))
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Reactivity
- Human, Mouse, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Collagen IV antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Purpose
- Collagen IV is a protein encoded by the COL4A1 gene which is approximately 160,6 kDa. Collagen IV is secreted into the extracellular space. It is involved in collagen chain trimerization, the integrin pathway, ERK signalling and focal adhesion. It is the major structural component of glomerular basement membranes and forms a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen. It specifically inhibits endothelial cell proliferation, migration and tube formation. Collagen IV is expressed in the nervous system, liver, lung, heart and kidney. Mutations in the COL4A1 gene may result in the tortuosity of retinal arteries. STJ98907 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody detects endogenous Collagen IV protein.
- Specificity
- The antibody detects endogenous Collagen IV protein.
- Characteristics
- Mouse Monoclonal to Collagen IV.
- Purification
- The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- synthetic peptide derived from Collagen IV.
- Top Product
- Discover our top product COL4 Primary Antibody
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- Application Notes
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IF 1:50-200
IHC-P 1:50-300 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- Collagen IV (COL4) (Collagen, Type IV (COL4))
- Alternative Name
- Collagen IV (COL4 Products)
- Synonyms
- collagen, type IV antibody, Let-2 antibody
- Molecular Weight
- 161kDa
- UniProt
- P02462
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