DOCK2 antibody

Catalog No. ABIN4903501

Product Details anti-DOCK2 Antibody

Target: DOCK2 (Dedicator of Cytokinesis 2 (DOCK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: A synthetic peptide of human DOCK2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:1000

Comment:

Specifically expressed in hematopoietic cells, Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen, Expressed at very low level in the small intestine and colon

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for DOCK2

Target: DOCK2 (Dedicator of Cytokinesis 2 (DOCK2))

Alternative Name: DOCK2 (DOCK2 Products)

Synonyms: AI662014 antibody, AW122239 antibody, CED-5 antibody, Hch antibody, MBC antibody, dedicator of cytokinesis 2 antibody, dedicator of cyto-kinesis 2 antibody, DOCK2 antibody, dock2 antibody, Dock2 antibody

Background: The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP.

Molecular Weight: 211.948 kDa

Gene ID: 1794

UniProt: Q92608