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SNX6 antibody

SNX6 Reactivity: Human WB Host: Mouse Monoclonal 5T6 unconjugated
Catalog No. ABIN4914189
  • Target See all SNX6 Antibodies
    SNX6 (Sorting Nexin 6 (SNX6))
    Reactivity
    • 34
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 27
    • 8
    Mouse
    Clonality
    • 27
    • 8
    Monoclonal
    Conjugate
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SNX6 antibody is un-conjugated
    Application
    • 23
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Human
    Purification
    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
    Immunogen
    This SNX6 monoclonal antibody is generated from mouse immunized with SNX6 recombinant protein.
    Clone
    5T6
    Isotype
    IgG1
    Top Product
    Discover our top product SNX6 Primary Antibody
  • Application Notes
    WB 1:300-5000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    SNX6 (Sorting Nexin 6 (SNX6))
    Alternative Name
    SNX6 (SNX6 Products)
    Synonyms
    MGC75952 antibody, MGC80251 antibody, im:7146294 antibody, wu:fa55b10 antibody, zgc:110798 antibody, MSTP010 antibody, TFAF2 antibody, 2010006G21Rik antibody, 2610032J07Rik antibody, 2810425K19Rik antibody, AU018928 antibody, C85963 antibody, sorting nexin 6 antibody, sorting nexin 6 L homeolog antibody, snx6 antibody, snx6.L antibody, SNX6 antibody, Snx6 antibody
    Background

    Synonyms: TFAF2, MSTP010, Sorting nexin-6, TRAF4-associated factor 2, SNX6

    Background: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

    Gene ID
    58533
    UniProt
    Q9UNH7
    Pathways
    EGFR Signaling Pathway
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