EGLN3 antibody (Internal Region)
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- Target See all EGLN3 Antibodies
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EGLN3 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Specificity
- Reacts with EGLN3 from human, mouse and rat
- Purification
- Purified (protein A)
- Immunogen
- Synthetic peptide of derived from internal part of human EGLN3.
- Top Product
- Discover our top product EGLN3 Primary Antibody
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- Application Notes
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC1:100 - 1:1000 WB1:200 - 1:2000 - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Must be reconstituted in distilled water.
- Concentration
- 1 mg/mL
- Buffer
- Tris 0,1M, glycine 0,1M, sucrose 2 %
- Storage
- 4 °C/-20 °C
- Storage Comment
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
- Expiry Date
- 24 months
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- Target
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- Alternative Name
- EGLN3 (EGLN3 Products)
- Synonyms
- zgc:77019 antibody, wu:fj78a08 antibody, EGLN3 antibody, phd3 antibody, PHD-3 antibody, PHD3 antibody, SM-20 antibody, 2610021G09Rik antibody, AI505553 antibody, AI648162 antibody, Hif-p4h-3 antibody, Phd3 antibody, HIFP4H3 antibody, HIFPH3 antibody, egl-9 family hypoxia-inducible factor 3 antibody, egl-9 family hypoxia inducible factor 3 antibody, egl-9 family hypoxia-inducible factor 3 L homeolog antibody, egln3 antibody, EGLN3 antibody, egln3.L antibody, Egln3 antibody
- Background
- Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site.
- Gene ID
- 112399
- UniProt
- Q9H6Z9
- Pathways
- Positive Regulation of Endopeptidase Activity
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