Filaggrin antibody (AA 1-261)

Catalog No. ABIN4951046

Product Details anti-Filaggrin Antibody

Target: Filaggrin (FLG)

Binding Specificity: AA 1-261

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Filaggrin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids 1-261 of human Filaggrin were used as the immunogen for the Filaggrin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Filaggrin antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Filaggrin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Filaggrin

Target: Filaggrin (FLG)

Alternative Name: Filaggrin (FLG Products)

Synonyms: AW107830 antibody, ft antibody, FLG antibody, ATOD2 antibody, Pflg antibody, Flg antibody, filaggrin antibody, Flg antibody, FLG antibody, LOC100351762 antibody, LOC100728006 antibody

Background: In humans, profillagrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance