HDAC11 antibody

Catalog No. ABIN4951281

Product Details anti-HDAC11 Antibody

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids NFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLN of human HDAC11 were used as the immunogen for the HDAC11 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HDAC11 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the HDAC11 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for HDAC11

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Alternative Name: HDAC11 (HDAC11 Products)

Synonyms: CG31119 antibody, DHDACX antibody, Dmel\\CG31119 antibody, HDAC11 antibody, HDACX antibody, dHDAC11 antibody, dmHDA403 antibody, zgc:91942 antibody, HD11 antibody, histone deacetylase 11 antibody, Histone deacetylase 11 antibody, hypothetical protein antibody, HDAC11 antibody, hdac11 antibody, CpipJ_CPIJ001619 antibody, Bm1_15905 antibody, LOAG_18214 antibody, Hdac11 antibody

Background: Histone deacetylase 11 is a 39 kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. This gene encodes a class IV histone deacetylase. And the encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells. In addition, HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.

UniProt: Q96DB2