KIF3A antibody (AA 485-699)

Catalog No. ABIN4951540

Product Details anti-KIF3A Antibody

Target: KIF3A (Kinesin Family Member 3A (KIF3A))

Binding Specificity: AA 485-699

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF3A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids 485-699 of human KIF3A were used as the immunogen for the KIF3A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the KIF3A antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the KIF3A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for KIF3A

Target: KIF3A (Kinesin Family Member 3A (KIF3A))

Alternative Name: KIF3A (KIF3A Products)

Synonyms: FLA10 antibody, KLP-20 antibody, 111-11-71 antibody, 111-11-86 antibody, AW124694 antibody, Kif3 antibody, Kifl antibody, Kns3 antibody, kinesin family member 3A antibody, kinesin family member 3a antibody, KIF3A antibody, Kif3a antibody

Background: Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein (KAP3), and it transports protein complexes, nucleic acids and organelles towards the plus ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.

UniProt: Q9Y496

Pathways: Hedgehog Signaling