OPA1 antibody
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- Target See all OPA1 Antibodies
- OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This OPA1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- Antigen affinity
- Immunogen
- Amino acids EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEA of human OPA1 were used as the immunogen for the OPA1 antibody.
- Isotype
- IgG
- Top Product
- Discover our top product OPA1 Primary Antibody
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- Application Notes
- Optimal dilution of the OPA1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- Restrictions
- For Research Use only
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Storage
- -20 °C
- Storage Comment
- After reconstitution, the OPA1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Target
- OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
- Alternative Name
- OPA1 (OPA1 Products)
- Synonyms
- 1200011N24Rik antibody, AI225888 antibody, AI847218 antibody, lilr3 antibody, mKIAA0567 antibody, MGM1 antibody, NPG antibody, NTG antibody, largeG antibody, fk62d06 antibody, wu:fb77a10 antibody, wu:fk62d06 antibody, zgc:92092 antibody, OPA1, mitochondrial dynamin like GTPase antibody, optic atrophy 1 (autosomal dominant) antibody, Opa1 antibody, OPA1 antibody, opa1 antibody
- Background
- Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
- UniProt
- O60313
- Pathways
- Tube Formation
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