Androgen Receptor antibody (AA 282-309)

Catalog No. ABIN3029942

The Rabbit Polyclonal anti-Androgen Receptor antibody is suitable to detect Androgen Receptor in samples from Human. It has been validated for WB and ELISA.

Quick Overview for Androgen Receptor antibody (AA 282-309) (ABIN3029942)

Target: Androgen Receptor (AR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Androgen Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Androgen Receptor Antibody

Binding Specificity: AA 282-309

Cross-Reactivity (Details): Expected species reactivity: Primate

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 282-309 from the human protein was used as the immunogen for this AR antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the AR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the AR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Androgen Receptor

Target: Androgen Receptor (AR)

Alternative Name: AR

Background: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding