PDX1 antibody (pThr11)

Catalog No. ABIN3032148

The Rabbit Polyclonal anti-PDX1 antibody (ABIN3032148) specifically detects PDX1 in ELISA, IF and DB. The antibody is reactive with Human samples.

Quick Overview for PDX1 antibody (pThr11) (ABIN3032148)

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDX1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Dot Blot (DB)

Product Details anti-PDX1 Antibody

Binding Specificity: pThr11

Purpose: Phospho-PDX1 Antibody (pT11)

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat

Purification: Antigen affinity

Immunogen: This phospho-PDX1 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT11 of human PDX1.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the phospho-PDX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-PDX1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PDX1

Target: PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))

Alternative Name: PDX1

Background: PDX1, Pancreas/duodenum homeobox protein 1, is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this protein are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

UniProt: P52945

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location